Lot of detail about Diablo 3 was picked up in the Q&A session at Blizzard Worldwide Invitational - the gameplay appears to stay mostly true to the original with isometric viewpoint with familiar solo and cooperative play modes, but with a lot of incremental improvements.
One detail that came up during the Q&A was an inquiry about the Diablo 3 system requirements. While the system requirements are not yet set, Blizzard's goal is to support a broad set of systems (as they have always done). They couldn't say if the game would run on any system that can run World of Warcraft today (my guess is "most likely not"), but they did confirm that Diablo 3 would not require DirectX 10. As Blizzard has never aimed for the cutting edge technologies, it's not really a surprise, but a definite word is always nice.
Blizzard still has Starcraft 2 and Wrath of the Lich King in the pipeline before Diablo 3, and some of the answers in the Q&A indicated that Diablo 3 is still very much work in progress, so it may be a while before we see Diablo 3. As there is no release date yet, even if D3 would end up requiring a solid DX9 card, something like a GeForce 7900GT or Radeon X1900 series, that would be almost nothing as a requirement if the game won't come out until late 2009 or early 2010. Even the cheapest budget video cards on the market by then would surpass such a requirement - even on laptops.
Many signs pointing to Diablo III announcement this weekend
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Diablo 3 confirmed